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KMID : 1161420100130010219
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Journal of Medicinal Food
2010 Volume.13 No. 1 p.219 ~ p.222
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Antidepressant-Like Activity of Sonchus oleraceus in Mouse Models of Immobility Tests
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Vilela Fabiana Cardoso
de Mesquita Padilha Marina
Alves-Da-Silva Geraldo
Soncini Roseli
Giusti-Paiva Alexandre
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Abstract
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The aim of the present work is to evaluate the putative antidepressant-like effects of hydroethanolic and dichloromethanic extracts from the aerial parts of Sonchus oleraceus (Family Asteraceae) on the performance of male mice in the forced swimming test (FST) and tail suspension test (TST) models predictive of depression. The hydroethanolic and dichloromethanic extracts, both in doses of 30, 100, and 300?mg/kg, were orally administered 1 hour before carrying out the FST or the TST. The immobility time in both the FST and the TST was significantly reduced by acute oral treatment with the extracts (dose range, 100?300?mg/kg), without accompanying changes in ambulation, as assessed in an open-field test. This excluded the possibility that the effect of the extracts is due to an activation of locomotion. The efficacy of the extracts was found to be comparable to that of amitriptyline (10?mg/kg, p.o.). The present study provides evidence for an antidepressant-like effect of the active principle(s) present in the extracts of S. oleraceus in mice. Therefore, a standardized S. oleraceus extract or its purified constituents could be of potential interest for the treatment of depressive disorders.
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KEYWORD
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Asteraceae, depression, forced swimming test, Sonchus oleraceus, tail suspension test
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